Impact of HIV Drug Resistance on HIV/AIDS-Associated Mortality, New Infections, and Antiretroviral Therapy Program Costs in Sub–Saharan Africa

نویسندگان

  • Andrew N. Phillips
  • John Stover
  • Valentina Cambiano
  • Fumiyo Nakagawa
  • Michael R. Jordan
  • Deenan Pillay
  • Meg Doherty
  • Paul Revill
  • Silvia Bertagnolio
چکیده

To inform the level of attention to be given by antiretroviral therapy (ART) programs to HIV drug resistance (HIVDR), we used an individual-level model to estimate its impact on future AIDS deaths, HIV incidence, and ART program costs in sub-Saharan Africa (SSA) for a range of program situations. We applied this to SSA through the Spectrum-Goals model. In a situation in which current levels of pretreatment HIVDR are over 10% (mean, 15%), 16% of AIDS deaths (890 000 deaths), 9% of new infections (450 000), and 8% ($6.5 billion) of ART program costs in SSA in 2016-2030 will be attributable to HIVDR.

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عنوان ژورنال:

دوره 215  شماره 

صفحات  -

تاریخ انتشار 2017